Think about the following facts:
1. The first species that crawled out of the muck and mire with cannabinoid receptors and production was hundreds of millions of years ago – probably.
2. Cannabis the plant appeared approximately 100,000 years ago – probably.
3. For certain, the plant came a very, very long time after the presence of cannabinoids and cannabinoid receptors
4. Only humans can prepare the medication, or ACTIVATE it, although every species will be effected after activation
So, just to make the point, I feel that the cannabis plant and man have a special connection as man is only direct benefactor. In the natural green plant, THC, CBD and the other cannabinoids we love so much, are in their “acid” form. In other words, THC is actually THC-A in the plant and has no currently known effect on brains. It is not active, until the COOH or acid group is removed allowing the THC to now “fit” into our receptors.
Pretty interesting stuff.