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CANNABIDIOL REFERENCES

1. Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine.
Bergamaschi MM, Barnes A, Queiroz RH, Hurd YL, Huestis MA.
Anal Bioanal Chem. 2013 Mar 15. [Epub ahead of print]
PMID: 23494274 [PubMed – as supplied by publisher]
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2. Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy.
Casarejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, de Yebenes JG, Mena MA.
J Alzheimers Dis. 2013 Mar 11. [Epub ahead of print]
PMID: 23478312 [PubMed – as supplied by publisher]
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3. Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.
Sylantyev S, Jensen TP, Ross RA, Rusakov DA.
Proc Natl Acad Sci U S A. 2013 Mar 7. [Epub ahead of print]
PMID: 23472002 [PubMed – as supplied by publisher] Free Article
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4. Industrial hemp decreases intestinal motility stronger than indian hemp in mice.
Sabo A, Horvat O, Stilinovic N, Berenji J, Vukmirovic S.
Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):486-90.
PMID: 23467947 [PubMed – in process]
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5. A GPR18-based signaling system regulates IOP in murine eye.
Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A.
Br J Pharmacol. 2013 Mar 5. doi: 10.1111/bph.12136. [Epub ahead of print]
PMID: 23461720 [PubMed – as supplied by publisher]
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6. Cannabis, psychosis and the thalamus: Some new theoretical concepts and insights.
Vukadinovic Z, Herman MS, Rosenzweig I.
Neurosci Biobehav Rev. 2013 Feb 28. doi:pii: S0149-7634(13)00049-3. 10.1016/j.neubiorev.2013.02.013. [Epub ahead of print]
PMID: 23458778 [PubMed – as supplied by publisher]
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7. The effects of cannabidiol on the antigen-induced contraction of airways smooth muscle in the guinea-pig.
Dudášová A, Keir SD, Parsons ME, Molleman A, Page CP.
Pulm Pharmacol Ther. 2013 Feb 18. doi:pii: S1094-5539(13)00059-X. 10.1016/j.pupt.2013.02.002. [Epub ahead of print]
PMID: 23428645 [PubMed – as supplied by publisher]
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8. [Marihuana and cannobinoids as medicaments].
Tkaczyk M, Florek E, Piekoszewski W.
Przegl Lek. 2012;69(10):1095-7. Polish.
PMID: 23421098 [PubMed – in process]
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9. Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss?
Le Foll B, Trigo JM, Sharkey KA, Strat YL.
Med Hypotheses. 2013 Feb 11. doi:pii: S0306-9877(13)00042-X. 10.1016/j.mehy.2013.01.019. [Epub ahead of print]
PMID: 23410498 [PubMed – as supplied by publisher]
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10. A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany.
Flachenecker P.
Expert Rev Neurother. 2013 Feb;13(3 Suppl 1):15-9. doi: 10.1586/ern.13.1.
PMID: 23369055 [PubMed – in process]
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11. Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.
García-Merino A.
Expert Rev Neurother. 2013 Feb;13(3 Suppl 1):9-13. doi: 10.1586/ern.13.4.
PMID: 23369054 [PubMed – in process]
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12. Development and validation of an LC-MS/MS method for quantification of Δ9-tetrahydrocannabinolic acid A (THCA-A), THC, CBN and CBD in hair.
Roth N, Moosmann B, Auwärter V.
J Mass Spectrom. 2013 Feb;48(2):227-33. doi: 10.1002/jms.3152.
PMID: 23378095 [PubMed – in process]
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13. Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme.
Hernán Pérez de la Ossa D, Lorente M, Gil-Alegre ME, Torres S, García-Taboada E, Aberturas Mdel R, Molpeceres J, Velasco G, Torres-Suárez AI.
PLoS One. 2013;8(1):e54795. doi: 10.1371/journal.pone.0054795. Epub 2013 Jan 22.
PMID: 23349970 [PubMed – in process] Free PMC Article
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14. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.
Chagas MH, Crippa JA, Zuardi AW, Hallak JE, Machado-de-Sousa JP, Hirotsu C, Maia L, Tufik S, Andersen ML.
J Psychopharmacol. 2013 Mar;27(3):312-6. doi: 10.1177/0269881112474524. Epub 2013 Jan 23.
PMID: 23343597 [PubMed – in process]
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15. Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19.
Jiang R, Yamaori S, Okamoto Y, Yamamoto I, Watanabe K.
Drug Metab Pharmacokinet. 2013 Jan 15. [Epub ahead of print]
PMID: 23318708 [PubMed – as supplied by publisher] Free Article
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16. Cannabidiol enhances consolidation of explicit fear extinction in humans.
Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ.
Psychopharmacology (Berl). 2013 Jan 10. [Epub ahead of print]
PMID: 23307069 [PubMed – as supplied by publisher]
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17. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
Campos AC, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC, Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA, Guzmán M, Galve-Roperh I, Guimarães FS.
Int J Neuropsychopharmacol. 2013 Jan 9:1-13. [Epub ahead of print]
PMID: 23298518 [PubMed – as supplied by publisher]
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18. Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR.
Happyana N, Agnolet S, Muntendam R, Van Dam A, Schneider B, Kayser O.
Phytochemistry. 2013 Mar;87:51-9. doi: 10.1016/j.phytochem.2012.11.001. Epub 2012 Dec 29.
PMID: 23280038 [PubMed – in process]
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19. Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.
Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.
Genes Cancer. 2012 Jul;3(7-8):512-20. doi: 10.1177/1947601912466556.
PMID: 23264851 [PubMed] Free PMC Article
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20. Endocannabinoid system and mood disorders: Priming a target for new therapies.
Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F.
Pharmacol Ther. 2013 Apr;138(1):18-37. doi: 10.1016/j.pharmthera.2012.12.002. Epub 2012 Dec 20.
PMID: 23261685 [PubMed – in process]
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21. Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target.
Soroceanu L, Murase R, Limbad C, Singer E, Allison J, Adrados I, Kawamura R, Pakdel A, Fukuyo Y, Nguyen D, Khan S, Arauz R, Yount GL, Moore DH, Desprez PY, McAllister SD.
Cancer Res. 2013 Mar 1;73(5):1559-69. doi: 10.1158/0008-5472.CAN-12-1943. Epub 2012 Dec 13.
PMID: 23243024 [PubMed – in process]
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22. What place for ▾ cannabis extract in MS?
[No authors listed]
Drug Ther Bull. 2012 Dec;50(12):141-4. doi: 10.1136/dtb.2012.11.0150.
PMID: 23241565 [PubMed – in process]
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23. Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse.
Al Saabi A, Allorge D, Sauvage FL, Tournel G, Gaulier JM, Marquet P, Picard N.
Drug Metab Dispos. 2013 Mar;41(3):568-74. doi: 10.1124/dmd.112.047878. Epub 2012 Dec 10.
PMID: 23230132 [PubMed – in process]
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24. COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.
Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B.
Mol Cancer Ther. 2013 Jan;12(1):69-82. doi: 10.1158/1535-7163.MCT-12-0335. Epub 2012 Dec 7.
PMID: 23220503 [PubMed – in process]
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25. Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.
Barro-Soria R, Stindl J, Müller C, Foeckler R, Todorov V, Castrop H, Strauß O.
PLoS One. 2012;7(11):e49624. doi: 10.1371/journal.pone.0049624. Epub 2012 Nov 20.
PMID: 23185387 [PubMed – in process] Free PMC Article
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26. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.
Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S.
J Neurol. 2012 Nov 21. [Epub ahead of print]
PMID: 23180178 [PubMed – as supplied by publisher]
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27. A phase I study to assess the single and multiple dose pharmacokinetics of THC/CBD oromucosal spray.
Stott CG, White L, Wright S, Wilbraham D, Guy GW.
Eur J Clin Pharmacol. 2012 Nov 22. [Epub ahead of print]
PMID: 23179176 [PubMed – as supplied by publisher]
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28. Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice.
Karmaus PW, Wagner JG, Harkema JR, Kaminski NE, Kaplan BL.
J Immunotoxicol. 2012 Nov 23. [Epub ahead of print]
PMID: 23173851 [PubMed – as supplied by publisher]
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29. Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration?
Lee D, Karschner EL, Milman G, Barnes AJ, Goodwin RS, Huestis MA.
Drug Alcohol Depend. 2012 Nov 9. doi:pii: S0376-8716(12)00411-5. 10.1016/j.drugalcdep.2012.10.011. [Epub ahead of print]
PMID: 23146820 [PubMed – as supplied by publisher]
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30. An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics.
Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT.
J Pain Symptom Manage. 2012 Nov 7. doi:pii: S0885-3924(12)00439-3. 10.1016/j.jpainsymman.2012.07.014. [Epub ahead of print]
PMID: 23141881 [PubMed – as supplied by publisher]
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31. Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test.
Almeida V, Levin R, Peres FF, Niigaki ST, Calzavara MB, Zuardi AW, Hallak JE, Crippa JA, Abílio VC.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Mar 5;41:30-5. doi: 10.1016/j.pnpbp.2012.10.024. Epub 2012 Nov 2.
PMID: 23127569 [PubMed – in process]
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32. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation.
Bolognini D, Rock E, Cluny N, Cascio M, Limebeer C, Duncan M, Stott C, Javid F, Parker L, Pertwee R.
Br J Pharmacol. 2013 Mar;168(6):1456-1470. doi: 10.1111/bph.12043.
PMID: 23121618 [PubMed – as supplied by publisher]
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33. Medical use of cannabis. Cannabidiol: a new light for schizophrenia?
Deiana S.
Drug Test Anal. 2013 Jan;5(1):46-51. doi: 10.1002/dta.1425. Epub 2012 Oct 25.
PMID: 23109356 [PubMed – in process]
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34. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.
Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS.
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3364-78. doi: 10.1098/rstb.2011.0389.
PMID: 23108553 [PubMed – in process]
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35. Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities.
Pertwee RG.
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3353-63. doi: 10.1098/rstb.2011.0381.
PMID: 23108552 [PubMed – in process]
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36. N-Arachidonyl glycine does not activate G protein-coupled receptor 18 signaling via canonical pathways.
Lu VB, Puhl HL 3rd, Ikeda SR.
Mol Pharmacol. 2013 Jan;83(1):267-82. doi: 10.1124/mol.112.081182. Epub 2012 Oct 25.
PMID: 23104136 [PubMed – in process]
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37. Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
O’Brien LD, Wills KL, Segsworth B, Dashney B, Rock EM, Limebeer CL, Parker LA.
Pharmacol Biochem Behav. 2013 Jan;103(3):597-602. doi: 10.1016/j.pbb.2012.10.008. Epub 2012 Oct 25.
PMID: 23103902 [PubMed – in process]
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38. Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report.
Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW.
J Clin Pharm Ther. 2013 Apr;38(2):162-4. doi: 10.1111/jcpt.12018. Epub 2012 Oct 24.
PMID: 23095052 [PubMed – in process]
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39. Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis.
Barichello T, Ceretta RA, Generoso JS, Moreira AP, Simões LR, Comim CM, Quevedo J, Vilela MC, Zuardi AW, Crippa JA, Teixeira AL.
Eur J Pharmacol. 2012 Dec 15;697(1-3):158-64. doi: 10.1016/j.ejphar.2012.09.053. Epub 2012 Oct 16.
PMID: 23085269 [PubMed – in process]
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40. Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.
Nabissi M, Morelli MB, Santoni M, Santoni G.
Carcinogenesis. 2013 Jan;34(1):48-57. doi: 10.1093/carcin/bgs328. Epub 2012 Oct 18.
PMID: 23079154 [PubMed – indexed for MEDLINE]
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41. A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray.
Stott CG, White L, Wright S, Wilbraham D, Guy GW.
Eur J Clin Pharmacol. 2012 Oct 4. [Epub ahead of print]
PMID: 23052407 [PubMed – as supplied by publisher]
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42. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment.
Englund A, Morrison PD, Nottage J, Hague D, Kane F, Bonaccorso S, Stone JM, Reichenberg A, Brenneisen R, Holt D, Feilding A, Walker L, Murray RM, Kapur S.
J Psychopharmacol. 2013 Jan;27(1):19-27. doi: 10.1177/0269881112460109. Epub 2012 Oct 5.
PMID: 23042808 [PubMed – in process]
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43. Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT(1A) receptor.
Gomes FV, Alves FH, Guimarães FS, Correa FM, Resstel LB, Crestani CC.
Eur Neuropsychopharmacol. 2012 Oct 4. doi:pii: S0924-977X(12)00271-4. 10.1016/j.euroneuro.2012.09.007. [Epub ahead of print]
PMID: 23041353 [PubMed – as supplied by publisher]
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44. [Treatment of spasticity in multiple sclerosis: new perspectives regarding the use of cannabinoids].
Oreja-Guevara C.
Rev Neurol. 2012 Oct 1;55(7):421-30. Spanish.
PMID: 23011861 [PubMed – in process] Free Article
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45. Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats.
Campos AC, de Paula Soares V, Carvalho MC, Ferreira FR, Vicente MA, Brandão ML, Zuardi AW, Zangrossi H Jr, Guimarães FS.
Psychopharmacology (Berl). 2013 Mar;226(1):13-24. doi: 10.1007/s00213-012-2878-7. Epub 2012 Sep 25.
PMID: 23007604 [PubMed – in process]
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46. Distribution of free and conjugated cannabinoids in human bile samples.
Fabritius M, Staub C, Mangin P, Giroud C.
Forensic Sci Int. 2012 Nov 30;223(1-3):114-8. doi: 10.1016/j.forsciint.2012.08.013. Epub 2012 Sep 11.
PMID: 22980143 [PubMed – in process]
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47. Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors.
Campos AC, Ferreira FR, Guimarães FS.
J Psychiatr Res. 2012 Nov;46(11):1501-10. doi: 10.1016/j.jpsychires.2012.08.012. Epub 2012 Sep 11.
PMID: 22979992 [PubMed – in process]
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48. Direct analysis of cannabis samples by desorption atmospheric pressure photoionization-mass spectrometry.
Kauppila TJ, Flink A, Laakkonen UM, Aalberg L, Ketola RA.
Drug Test Anal. 2013 Mar;5(3):186-90. doi: 10.1002/dta.1412. Epub 2012 Sep 13.
PMID: 22977002 [PubMed – in process]
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49. Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity.
Leussink VI, Husseini L, Warnke C, Broussalis E, Hartung HP, Kieseier BC.
Ther Adv Neurol Disord. 2012 Sep;5(5):255-66. doi: 10.1177/1756285612453972.
PMID: 22973422 [PubMed] Free PMC Article
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50. A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.
Granja AG, Carrillo-Salinas F, Pagani A, Gómez-Cañas M, Negri R, Navarrete C, Mecha M, Mestre L, Fiebich BL, Cantarero I, Calzado MA, Bellido ML, Fernandez-Ruiz J, Appendino G, Guaza C, Muñoz E.
J Neuroimmune Pharmacol. 2012 Dec;7(4):1002-16. doi: 10.1007/s11481-012-9399-3. Epub 2012 Sep 14.
PMID: 22971837 [PubMed – in process]
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51. “The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms.”
Bosier B, Muccioli GG, Lambert DM.
Br J Pharmacol. 2012 Sep 12. doi: 10.1111/j.1476-5381.2012.02208.x. [Epub ahead of print]
PMID: 22970888 [PubMed – as supplied by publisher]
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52. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.
Toxicol Lett. 2012 Nov 15;214(3):314-9. doi: 10.1016/j.toxlet.2012.08.029. Epub 2012 Sep 8.
PMID: 22963825 [PubMed – indexed for MEDLINE]
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53. Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis.
Podda G, Constantinescu CS.
Expert Opin Biol Ther. 2012 Nov;12(11):1517-31. doi: 10.1517/14712598.2012.721765. Epub 2012 Sep 7.
PMID: 22954177 [PubMed – in process]
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54. Fast liquid chromatography/tandem mass spectrometry determination of cannabinoids in micro volume blood samples after dabsyl derivatization.
Lacroix C, Saussereau E.
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 15;905:85-95. doi: 10.1016/j.jchromb.2012.08.006. Epub 2012 Aug 13.
PMID: 22921635 [PubMed – indexed for MEDLINE]
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55. On-site test for cannabinoids in oral fluid.
Desrosiers NA, Lee D, Schwope DM, Milman G, Barnes AJ, Gorelick DA, Huestis MA.
Clin Chem. 2012 Oct;58(10):1418-25. Epub 2012 Aug 21.
PMID: 22912396 [PubMed – indexed for MEDLINE]
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56. Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis.
Serpell MG, Notcutt W, Collin C.
J Neurol. 2013 Jan;260(1):285-95. doi: 10.1007/s00415-012-6634-z. Epub 2012 Aug 10.
PMID: 22878432 [PubMed – in process]
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57. Cannabidiol treatment ameliorates ischemia/reperfusion renal injury in rats.
Fouad AA, Al-Mulhim AS, Jresat I.
Life Sci. 2012 Sep 17;91(7-8):284-92. doi: 10.1016/j.lfs.2012.07.030. Epub 2012 Aug 1.
PMID: 22877651 [PubMed – indexed for MEDLINE]
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58. Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT(1A) receptors in the dorsal raphe nucleus.
Katsidoni V, Anagnostou I, Panagis G.
Addict Biol. 2013 Mar;18(2):286-96. doi: 10.1111/j.1369-1600.2012.00483.x. Epub 2012 Aug 2.
PMID: 22862835 [PubMed – in process]
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59. Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB(1) and CB(2) Receptors.
Valdeolivas S, Satta V, Pertwee RG, Fernández-Ruiz J, Sagredo O.
ACS Chem Neurosci. 2012 May 16;3(5):400-6. doi: 10.1021/cn200114w. Epub 2012 Feb 9.
PMID: 22860209 [PubMed]
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60. Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice.
Li K, Feng JY, Li YY, Yuece B, Lin XH, Yu LY, Li YN, Feng YJ, Storr M.
Pancreas. 2013 Jan;42(1):123-9. doi: 10.1097/MPA.0b013e318259f6f0.
PMID: 22850623 [PubMed – in process]
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61. Towards the use of non-psychoactive cannabinoids for prostate cancer.
Pacher P.
Br J Pharmacol. 2013 Jan;168(1):76-8. doi: 10.1111/j.1476-5381.2012.02121.x.
PMID: 22849856 [PubMed – in process]
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62. siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration.
McHugh D, Wager-Miller J, Page J, Bradshaw HB.
J Mol Signal. 2012 Jul 26;7(1):10. doi: 10.1186/1750-2187-7-10.
PMID: 22834922 [PubMed] Free PMC Article
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63. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.
Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D.
Transl Psychiatry. 2012 Mar 20;2:e94. doi: 10.1038/tp.2012.15.
PMID: 22832859 [PubMed – indexed for MEDLINE] Free PMC Article
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64. The atypical cannabinoid o-1602: targets, actions, and the central nervous system.
Ashton JC.
Cent Nerv Syst Agents Med Chem. 2012 Sep;12(3):233-9.
PMID: 22831390 [PubMed – in process]
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65. Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview.
Esposito G, Filippis DD, Cirillo C, Iuvone T, Capoccia E, Scuderi C, Steardo A, Cuomo R, Steardo L.
Phytother Res. 2012 Jul 20. doi: 10.1002/ptr.4781. [Epub ahead of print]
PMID: 22815234 [PubMed – as supplied by publisher]
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66. CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells.
Arnold JC, Hone P, Holland ML, Allen JD.
Pharmacol Rep. 2012;64(3):751-7.
PMID: 22814029 [PubMed – indexed for MEDLINE] Free Article
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67. New biocomposites based on bioplastic flax fibers and biodegradable polymers.
Wróbel-Kwiatkowska M, Czemplik M, Kulma A, Zuk M, Kaczmar J, Dymińska L, Hanuza J, Ptak M, Szopa J.
Biotechnol Prog. 2012 Sep-Oct;28(5):1336-46. doi: 10.1002/btpr.1599. Epub 2012 Aug 17.
PMID: 22807200 [PubMed – indexed for MEDLINE]
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68. Simultaneous quantification of free and glucuronidated cannabinoids in human urine by liquid chromatography tandem mass spectrometry.
Scheidweiler KB, Desrosiers NA, Huestis MA.
Clin Chim Acta. 2012 Nov 20;413(23-24):1839-47. doi: 10.1016/j.cca.2012.06.034. Epub 2012 Jul 6.
PMID: 22771478 [PubMed – indexed for MEDLINE]
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69. Comment on: “Anxiogenic-like effects of chronic cannabidiol administration in rats” (Elbatsh MM, Assareh N, Marsden CA, Kendall DA, Psychopharmacology 2012).
Gururajan A.
Psychopharmacology (Berl). 2012 Aug;222(4):725-6; author reply 727. doi: 10.1007/s00213-012-2780-3. Epub 2012 Jul 4. No abstract available.
PMID: 22760485 [PubMed – indexed for MEDLINE]
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70. Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress.
Mecha M, Torrao AS, Mestre L, Carrillo-Salinas FJ, Mechoulam R, Guaza C.
Cell Death Dis. 2012 Jun 28;3:e331. doi: 10.1038/cddis.2012.71.
PMID: 22739983 [PubMed – in process] Free PMC Article
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71. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.
Schier AR, Ribeiro NP, Silva AC, Hallak JE, Crippa JA, Nardi AE, Zuardi AW.
Rev Bras Psiquiatr. 2012 Jun;34 Suppl 1:S104-10. Review. English, Portuguese.
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146. The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus.
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148. Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats.
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151. Endocannabinoid system dysfunction in mood and related disorders.
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152. Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury.
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155. Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats.
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156. Identification of recent cannabis use: whole-blood and plasma free and glucuronidated cannabinoid pharmacokinetics following controlled smoked cannabis administration.
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165. Cannabinoids in oral fluid following passive exposure to marijuana smoke.
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166. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
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168. Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.
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178. Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease.
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180. Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.
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FOLLOWING GROUP ARE REFERENCED FROM DR. ETHAN RUSSO:

Taming THC: potential
cannabis synergy and
phytocannabinoid-terpenoid
entourage effects
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5: 17.

CBD and Cancer

http://www.ncbi.nlm.nih.gov/pubmed/20053780

http://www.ncbi.nlm.nih.gov/pubmed/16728591

http://www.ncbi.nlm.nih.gov/pubmed/21566064

http://www.ncbi.nlm.nih.gov/pubmed/18833429

Tumor Studies:

http://www.ncbi.nlm.nih.gov/pubmed/18035205

http://www.ncbi.nlm.nih.gov/pubmed/14617682

Clinical Trials:

http://clinicaltrials.gov/ct2/results?term=cannabidiol

http://www.cannabis-med.org/studies/ww_en_db_study_search.php

 

REFERENCES CITED BY GW PHARMACEUTICALS
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Mechoulam et al., "A Total Synthesis of d1-.DELTA..sup.1 -Tetrahydrocannabinol, the Active Constituent of Hashish.sup.1," Journal of the American Chemical Society, 87:14:3273-3275 (1965). .
Mechoulam et al., "Chemical Basis of Hashish Activity," Science, 18:611-612 (1970). .
Ottersen et al., "The Crystal and Molecular Structure of Cannabidiol," Acta Chem. Scand. B 31, 9:807-812 (1977). .
Cunha et al., "Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients.sup.1," Pharmacology, 21:175-185 (1980). .
Consroe et al., "Acute and Chronic Antiepileptic Drug Effects in Audiogenic Seizure-Susceptible Rats," Experimental Neurology, Academic Press Inc., 70:626-637 (1980). .
Turkanis et al., "Electrophysiologic Properties of the Cannabinoids," J. Clin. Pharmacol., 21:449S-463S (1981). .
Carlini et al., "Hypnotic and Antielpileptic Effects of Cannabidiol," J. Clin. Pharmacol., 21:417S-427S (1981). .
Karler et al., "The Cannabinoids as Potential Antiepileptics," J. Clin. Pharmacol., 21:437S-448S (1981). .
Consroe et al., "Antiepileptic Potential of Cannabidiol Analgos," J. Clin. Pharmacol., 21:428S-436S (1981). .
Colasanti et al., "Ocular Hypotension, Ocular Toxicity,a nd Neurotoxicity in Response to Marihuana Extract and Cannabidiol," Gen Pharm., Pergamon Press Ltd., 15(6):479-484 (1984). .
Colasanti et al., "Intraocular Pressure, Ocular Toxicity and Neurotoxicity after Administration of Cannabinol or Cannabigerol," Exp. Eye Res., Academic Press Inc., 39:251-259 (1984). .
Volfe et al., "Cannabinoids Block Release of Serotonin from Platelets Induced by Plasma frm Migraine Patients," Int. J. Clin. Pharm. Res., Bioscience Ediprint Inc., 4:243-246 (1985). .
Agurell et al., "Pharmacokinetics and Metabolism of .DELTA..sup.1 -Tetrahydrocannabinol and Other Cannabinoids with Emphasis on Man*," Pharmacological Reviews, 38(1):21-43 (1986). .
Karler et al., "Different Cannabinoids Exhibit Different Pharmacological and Toxicological Properties,"NIDA Res. Monogr., 79:96-107 (1987). .
Samara et al., "Pharmacokinetics of Cannabidiol in Dogs," Drug Metabolism and Disposition, 16(3):469-472 (1988). .
Choi, "Glutamate Neurotoxicity and Diseases of the Nervous System," Neuron, Cell Press, 1:623-634 (1988). .
Eshhar et al., "Neuroprotective and Antioxidant Activities of HU-211, A Novel NMDA Receptor Antagonist," European Journal of Pharmacology, 283:19-29 (1995). .
Skaper et al., "The ALIAmide Palmitoylethanolamide and Cannabinoids, but not Anandamide, are Protective in a Delayed Postglutamate Paradigm of Excitotoxic Death in Cerebellar Granule Neurons," Neurobiology, Proc. Natl. Acad. Sci. USA, 93:3984-3989 (1996). .
Alonso et al., "Simple Synthesis of 5-Substituted Resorcinols: A Revisited Family of Interesting Bioactive Molecules," J. Org. Chem., American Chemical Society, 62(2):417-421 (1997). .
Combes et al. "A Simple Synthesis of the Natural 2,5-Dialkylresorcinol Free Radical Scavenger Antioxidant: Resorstation," Synthetic Communications, Marcel Dekker, Inc., 27(21):3769-3778 (1997). .
Shohami et al., "Oxidative Stress in Closed-Head Injury: Brain Antioxidant Capacity as an Indicator of Functional Outcome," Journal of Cerebral Blood Flow and Metabolism, Lippincott-Raven Publishers, 17(10):1007-1019 (1997). .
Zurier et al., "Dimethylheptyl-THC-11 OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998). .
Hampson et al., "Dual Effects of Anandamide on NMDA Receptor-Mediated Responses and Neurotransmission," Journal of Neurochemistry, Lippincott-Raven Publishers, 70(2):671-676 (1998). .
Hampson et al., "Cannabidiol and (-).DELTA..sup.9 -tetrahydrocannabiono are Neuroprotective Antioxidants," Medical Sciences, Proc. Natl. Acad. Sci. USA, 8268-8273 (1998)..
Windholz et al., The Merck Index, Tenth Edition (1983) p. 241, abstract No. 1723.* .
Mechoulam et al., "A Total Synthesis of d1-.DELTA..sup.1 -Tetrahydrocannabinol, the Active Constituent of Hashish.sup.1," Journal of the American Chemical Society, 87:14:3273-3275 (1965). .
Mechoulam et al., "Chemical Basis of Hashish Activity," Science, 18:611-612 (1970). .
Ottersen et al., "The Crystal and Molecular Structure of Cannabidiol," Acta Chem. Scand. B 31, 9:807-812 (1977). .
Cunha et al., "Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients.sup.1," Pharmacology, 21:175-185 (1980). .
Consroe et al., "Acute and Chronic Antiepileptic Drug Effects in Audiogenic Seizure-Susceptible Rats," Experimental Neurology, Academic Press Inc., 70:626-637 (1980). .
Turkanis et al., "Electrophysiologic Properties of the Cannabinoids," J. Clin. Pharmacol., 21:449S-463S (1981). .
Carlini et al., "Hypnotic and Antielpileptic Effects of Cannabidiol," J. Clin. Pharmacol., 21:417S-427S (1981). .
Karler et al., "The Cannabinoids as Potential Antiepileptics," J. Clin. Pharmacol., 21:437S-448S (1981). .
Consroe et al., "Antiepileptic Potential of Cannabidiol Analgos," J. Clin. Pharmacol., 21:428S-436S (1981). .
Colasanti et al., "Ocular Hypotension, Ocular Toxicity,a nd Neurotoxicity in Response to Marihuana Extract and Cannabidiol," Gen Pharm., Pergamon Press Ltd., 15(6):479-484 (1984). .
Colasanti et al., "Intraocular Pressure, Ocular Toxicity and Neurotoxicity after Administration of Cannabinol or Cannabigerol," Exp. Eye Res., Academic Press Inc., 39:251-259 (1984). .
Volfe et al., "Cannabinoids Block Release of Serotonin from Platelets Induced by Plasma frm Migraine Patients," Int. J. Clin. Pharm. Res., Bioscience Ediprint Inc., 4:243-246 (1985). .
Agurell et al., "Pharmacokinetics and Metabolism of .DELTA..sup.1 -Tetrahydrocannabinol and Other Cannabinoids with Emphasis on Man*," Pharmacological Reviews, 38(1):21-43 (1986). .
Karler et al., "Different Cannabinoids Exhibit Different Pharmacological and Toxicological Properties,"NIDA Res. Monogr., 79:96-107 (1987). .
Samara et al., "Pharmacokinetics of Cannabidiol in Dogs," Drug Metabolism and Disposition, 16(3):469-472 (1988). .
Choi, "Glutamate Neurotoxicity and Diseases of the Nervous System," Neuron, Cell Press, 1:623-634 (1988). .
Eshhar et al., "Neuroprotective and Antioxidant Activities of HU-211, A Novel NMDA Receptor Antagonist," European Journal of Pharmacology, 283:19-29 (1995). .
Skaper et al., "The ALIAmide Palmitoylethanolamide and Cannabinoids, but not Anandamide, are Protective in a Delayed Postglutamate Paradigm of Excitotoxic Death in Cerebellar Granule Neurons," Neurobiology, Proc. Natl. Acad. Sci. USA, 93:3984-3989 (1996). .
Alonso et al., "Simple Synthesis of 5-Substituted Resorcinols: A Revisited Family of Interesting Bioactive Molecules," J. Org. Chem., American Chemical Society, 62(2):417-421 (1997). .
Combes et al. "A Simple Synthesis of the Natural 2,5-Dialkylresorcinol Free Radical Scavenger Antioxidant: Resorstation," Synthetic Communications, Marcel Dekker, Inc., 27(21):3769-3778 (1997). .
Shohami et al., "Oxidative Stress in Closed-Head Injury: Brain Antioxidant Capacity as an Indicator of Functional Outcome," Journal of Cerebral Blood Flow and Metabolism, Lippincott-Raven Publishers, 17(10):1007-1019 (1997). .
Zurier et al., "Dimethylheptyl-THC-11 OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998). .
Hampson et al., "Dual Effects of Anandamide on NMDA Receptor-Mediated Responses and Neurotransmission," Journal of Neurochemistry, Lippincott-Raven Publishers, 70(2):671-676 (1998). .
Hampson et al., "Cannabidiol and (-).DELTA..sup.9 -tetrahydrocannabiono are Neuroprotective Antioxidants," Medical Sciences, Proc. Natl. Acad. Sci. USA, 8268-8273 (1998)..

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