CBD-A OR CBD-ACID AND NAUSEA OF CHEMOTHERAPY AND MORE

There are plenty of times where nausea, particularly during chemotherapy, is helped by combined CBD:THC whole plant extracts. There are times I need to use a lot more THC an hour or so before a meal to help when CBD is clearly not effective.

In fact, the most common time I see CBD help with nausea, is when the nausea is related to anxiety. This is common and using whole plant CBD is a great help.

However, what should we do when THC either does not work well or the psychoactivity is just too much? Well, the literature below would suggest that CBD-ACID, or carboxylated CBD, might be of great benefit.

If you have used CBD-ACID with either success or failure, please message my office through my website

1.

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation.

Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG.

Br J Pharmacol. 2013 Mar;168(6):1456-70. doi: 10.1111/bph.12043.

PMID:
23121618

Free PMC Article

2.

Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.

Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, Mechoulam R, Pertwee RG, Parker LA.

Br J Pharmacol. 2012 Apr;165(8):2620-34. doi: 10.1111/j.1476-5381.2011.01621.x.

3.

Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats.

Rock EM, Parker LA.

Br J Pharmacol. 2013 Jun;169(3):685-92. doi: 10.1111/bph.12162.

PMID:
23488964

Free PMC Article

Author
Allan Frankel, MD

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