Over the past several months, I have had the honor of treating a number of patients with Schizophrenia. Some of these patients have been classified as having a more vague “schizo-affective” disorder. In either case, Cannabidiol has significant effects in reducing hallucinations, paranoia and other thought disorders associated with schizophrenia.

There are some studies by Dr. Matthew Jones et al. at Bristol University UK, out of England, suggesting that THC may aggravate or even incite this disorder. Further studies have shown this to be untrue, but THC certainly can effect these patients in somewhat unpredictable ways; at times improving and at times worsening symptoms.

On the other hand, CBD or cannabidiol appears to be very effective and safe. We have know for a number of years that CBD does not have much action on the CB1 and CB2 receptors. So, it has been unclear as to how CBD might work in these and other patients.

In this article, a possible mechanism of CBD is discussed. In addition, at the bottom of this post, I have listed all the references for this article.

It appears that CBD increases the Anandamide level in our brains. Again, Anandamide is our internal “endocannabinoid” that is similar in most respects to THC. So, CBD leads to increased Anandamide by decreasing the level of an enzyme, FAAH, that breaks down Anandamide. In summary, CBD blocks the action of the enzyme that breaks down Anandamide. Increased brain and serum Anandamide lead to improved mood and decreased pain.

This may explain why CBD APPEARS to effect cannabinoid receptors, but in fact also largely works by increasing our internal THC or Anandamide. This may also explain the apparent “Reverse Tolerance” that we often see clinically.


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Allan Frankel, MD Dr Allan Frankel is one of the few physicians in the US who truly understands Cannabis as a medicine. All treatments suggested have been well studied. Every patient seen by Dr Frankel is given a personally created Treatment Plan created with the patient's specific issues defined. Plant medicine requires "tuning" of the dosing. Dr Frankel works with his patients thru a messaging portal. The use of this portal, allows quick and simple follow up contact with Dr Frankel. Patients are not charged for these messages, as this is how Dr Frankel has learned what he has learned. Follow up appointments in person or by phone/video are also available when needed

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