I have been following a young male with relatively severe Crohn’s disease. He has been on an assorted group of meds without adequate control.
He first presented to me nearly a year ago and has done very well on CBD whole plant capsules. He required a total daily dose of 95 mg of CBD per day.
Recently he switched over to using rectal administration of 20 mg BID with the same control as with 95 mg orally.
I am not suggesting this is any final answer to the “issues of the rectum”, but it certainly is an important small piece.
We are actively looking for labs that will measure CBD and THC and hopefully the endocannabinoids as well. This would allow us to settle the issues related to rectal vs oral vs oral buccal.
In the meantime, for pelvic or bowel disease, please consider rectal administration.