In my most recent blog entry, I discussed THC-Acid (THC-A) and it’s effects on mitochondria, as well as a number of other organs. Pertaining to this specifically, two of the major effects of THC-A are:
- increased intra-cellular energy due to increased formation of Adenosine Tri-Phosphate (ATP,) our major source of useable energy in every cell other than red blood cells, and
- anti-spasmodic effects on many muscles, including bladder and prostate related smooth muscle “valves.”
With many myopathies, or diseases associated with muscle weakness, THC-A is helpful in restoring muscle energy and function, while being anti-spasmodic at the same time. This may seem contrary, but relaxed muscles with enhanced energy simply work more efficiently.
Additionally, THC-A has been utilized in multiple conditions wherein smooth muscle or skeletal muscle is in frequent spasm, which leads to my belief that it can be equally effective in relation to the urinary tract.
I have noted for a number of years that 1:1 combinations of CBD:THC-A are very beneficial for urinary urgency, spasm and frequency. The anti-inflammatory benefits of THC-A, as well as CBD, should be of additional help for this and other conditions in which inflammation is an issue. The same formulation is actually showing some early promise for inflammatory bowel disease.
With relatively low doses of CBD:THC-A, patients have found that frequency and urgency generally substantially improve within a few days. However, as I have not yet had the chance to recommend treatment with THC-A alone, I welcome the opportunity. It is clear that more trials are necessary to determine and evaluate it’s individual efficacy in this regard.